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Recertification according to Council Regulation (EC) No 834/2007 (BIO certificate)

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Conversion of the plant control system

QUALITY MANAGEMENT


Particle size analyses


There is a variety of methods and devices for determining the particle size of a substance. Each unit covers only part of the problem in terms of material usability, measurement and analysis range, accuracy, reproducibility, handling, etc.
Frequent questions to determine the most appropriate measurement method and apparatus are:
  • Which fineness range is relevant?
  • What role does the analysis time play?
  • Which substance must be analysed?



Methods for particle size analysis


a. Laser diffraction

During a laser diffraction analysis, which is the standard analysis for in-process control, the diffraction spectrum of a laser beam is measured at a particle collective. The equivalent diameter of spherical particles which produce the same diffraction pattern can be calculated from the intensity distribution.

Advantages:
  • Very fast measurement
  • Wide measuring range from 0.1 to 875 µm

Disadvantages:
  • The sample material should not be transparent.

Sympatec HELOS BF


b. Sieve analysis

By sieving the residue the mass distribution can be determined.
The sieve analyses are performed with certified stainless steel screens. There is a variety of mesh sizes available. Depending on the product characteristics vibration screens or air jet sieves are used.









Image: © BMK Wikimedia

Sieves with different mesh sizes



Sieving processes can be carried out by means of different techniques, most of which differ in the movement which is transferred to the material to be screened. A distinction is made between Horizontal sieving and tapping sieving. In a horizontal sieve shaker the sieve stack moves in horizontal circles in a plane. During a tapping sieving a horizontal circular motion overlies a vertical motion which is created by a tapping impulse.

Advantages:
  • The particle size is determined by the sieve mesh size and not calculated indirectly
  • Excellent reproducibility with careful implementation
  • Analysis of large sample volumes is possible

Disadvantages:
  • Dry sieving analysis only possible > 25 µm

ALPINE Air Jet Sieve
 W.S. TYLER® Ro-Tap® RX-29 Sieve Shaker






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ACU PHARMA und CHEMIE GmbH
Am tiefen Graben 6, DE-99510 Apolda
Phone: +49 (0)3644 5058-0
Fax:     +49 (0)3644 5058-99
www.acu-pharma.com
contact(at)acu-pharma.com